Siim Land Podcast #482 Why Scientists Believe Lithium May Be a Longevity Molecule
Dec 5, 2025
Jon Berner, MD PhD, a Seattle-based psychiatrist and lithium researcher, delves into why lithium could be a revolutionary longevity molecule. He discusses how low doses might reduce dementia and suicidality, and the fascinating mechanisms behind its effects on mTOR and autophagy. Berner shares insights on the optimal dosing, safety concerns, and personal experiences with lithium. He also touches on the potential benefits for those with bipolar traits and explores the synergy between lithium and rapamycin, all while advocating for personalized treatment approaches.
AI Snips
Chapters
Transcript
Episode notes
Lithium As A Population-Level Modulator
- Lithium may lower Alzheimer's risk and stabilize mood by subtly shifting cellular growth/activity trade-offs.
- Random natural lithium exposure shows population-level benefits in longevity and suicide reduction.
mTORC2 Modulation And Cellular Maintenance
- Lithium likely down-regulates mTORC2 and reduces neuronal overdrive, indirectly promoting autophagy.
- This shift may improve maintenance processes like mitophagy and slow cellular senescence.
Telomere Change In Lithium Patients
- Martin Scharf's telomere data showed bipolar patients on lithium had longer telomeres within six months.
- That finding motivated Jon Berner to explore lithium's rejuvenation signals clinically.