Jon Berner
Board-certified psychiatrist and researcher with decades of clinical experience studying lithium and its effects on mood disorders and neurodegeneration; author of related scientific publications and practicing psychiatrist in Seattle.
Best podcasts with Jon Berner
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Oct 24, 2024 • 1h 3min
Brain Repair: The Ketamine Combo Treatment for Depression and Chronic Pain | 75
In this engaging discussion, board-certified psychiatrist Jon Berner delves into the transformative potential of ketamine and rapamycin in treating severe depression and chronic pain. He explains how these treatments impact microglia, facilitating a shift from inflammation to repair. Listeners will find intriguing insights on case studies, regulatory reforms, and the complexity of mast cell disorders. Jon also sheds light on the therapeutic possibilities for addiction and the importance of innovative, individualized approaches in mental health care.
Dec 5, 2025 • 1h 2min
#482 Why Scientists Believe Lithium May Be a Longevity Molecule
Jon Berner, MD PhD, a Seattle-based psychiatrist and lithium researcher, delves into why lithium could be a revolutionary longevity molecule. He discusses how low doses might reduce dementia and suicidality, and the fascinating mechanisms behind its effects on mTOR and autophagy. Berner shares insights on the optimal dosing, safety concerns, and personal experiences with lithium. He also touches on the potential benefits for those with bipolar traits and explores the synergy between lithium and rapamycin, all while advocating for personalized treatment approaches.
