What Dr. Peter Attia Gets Wrong About DNAm Aging Clocks
Dec 6, 2023
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The hosts debunk Dr. Peter Attia's points about the predictive value of aging clocks and offer an updated view. They discuss the evolution of epigenetic clocks and the use of multi-omic markers for disease prediction. The significance of longitudinal data in biologic age testing is explored, along with the benefits of the Dine and Pace method for assessing stress response. Advancements in understanding DNA methylation aging clocks and the importance of using blood tests for accuracy are also discussed.
The new generation of biological clocks, such as Dunedin Pace and Omic Age, provide improved precision and reduced variability compared to previous clocks, allowing for accurate estimation of biological age and prediction of disease risk and mortality.
The practical application of these clocks allows for personalized health decisions, interventions, and lifestyle changes, providing insights into specific organ systems and measuring the effectiveness of interventions in slowing down aging and improving health outcomes.
Deep dives
New generation clocks estimate biological age accurately
The podcast episode discusses the new generation of clocks that accurately estimate biological age. These clocks, such as Dunedin Pace and Omic Age, have improved precision and reduced variability compared to previous clocks. They take into account longitudinal data, tracking changes in biomarkers over time, and can predict the risk of diseases and mortality with high accuracy. The clocks also provide insights into specific organ systems and potential interventions. The podcast emphasizes the practical application of these clocks for individual health decisions and shows how they can guide interventions and measure the effectiveness of lifestyle changes.
Addressing criticisms and limitations of biological clocks
The podcast addresses several criticisms and limitations of biological clocks raised in the episode. It highlights the progress made in addressing these concerns. For example, the issue of limited insight into lifespan and geo-protective interventions is countered by the ability of newer clocks to provide actionable insights into expected lifespan and assess the efficacy of interventions. The podcast also discusses how variability across cell types and technical noise have been addressed to improve the accuracy and precision of these clocks. Additionally, the podcast emphasizes the value of methylation being influenced by lifestyle factors, as it allows for a better assessment of how one's behavior impacts their biological age.
The potential of biological clocks in personalized health optimization
The podcast explores the potential of biological clocks in personalized health optimization. It highlights how these clocks can offer specific insights into the aging process and identify potential interventions to slow down aging and improve health outcomes. The ability to track changes in biomarkers and phenotypic markers allows for a more targeted approach to health management and decision-making. The podcast emphasizes the importance of incorporating these clocks into comprehensive health optimization plans, along with genomics, blood work, and lifestyle assessments, to create personalized plans for individuals.
Using biological clocks to guide interventions and measure progress
The podcast discusses how biological clocks can be used to guide interventions and track progress in health optimization. It highlights the value of regular testing and retesting to measure the impact of lifestyle changes and interventions on biological age. The ability to estimate the impact of specific interventions, such as dietary changes, supplements, and senolytics, provides individuals with insights into the effectiveness of their efforts. The podcast emphasizes the actionable nature of these clocks, allowing individuals to make informed decisions and actively work towards slowing down aging and improving health.
Our Founders, Dr.'s Mike Mallin and Matt Dawson take a second look at Dr. Peter Attia's recent paper about biological aging and offer a more updated view. They dive into epigenetic clocks and methylation, taking a look at how these tests have evolved in the past five years. We touch on how the use of multi-omic markers (phenotypic data, metablymic, and protiomics) has become more accurate in predicting disease and rate of mortality.
We break down Peter's points, some they agree with...and some not so much. We debunk multiple of Dr. Attia's points about the predictive value and other concerns with new research. We also take a look at the future of testing and their optimism around this science.
Our hosts do a great job of breaking down this complex science that goes into epigenetic testing and the major breakthrough that is this fourth generation of DNAm Age testing, sharing their personal experiences and practical use.
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