Advancements in Epigenetic Aging Clocks

Our Founders, Dr.'s Mike Mallin and Matt Dawson take a second look at Dr. Peter Attia's recent paper about biological aging and offer a more updated view. They dive into epigenetic clocks and methylation, taking a look at how these tests have evolved in the past five years. We touch on how the use of multi-omic markers (phenotypic data, metablymic, and protiomics) has become more accurate in predicting disease and rate of mortality.

We break down Peter's points, some they agree with...and some not so much. We debunk multiple of Dr. Attia's points about the predictive value and other concerns with new research. We also take a look at the future of testing and their optimism around this science.

Our hosts do a great job of breaking down this complex science that goes into epigenetic testing and the major breakthrough that is this fourth generation of DNAm Age testing, sharing their personal experiences and practical use.

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Resources:

1. Peter's Article referenced: https://peterattiamd.com/how-accurate-are-biological-age-clocks/

2. Response to Dr. Peter Attia: https://drive.google.com/file/d/1d3HV0QkHqslo4FdOQfWKSp44tzEmQPZj/view?usp=sharing

3. OMICmAge: An integrative multi-omics approach to quantify biological age with electronic medical records: https://www.biorxiv.org/content/10.1101/2023.10.16.562114v1

4. OMICmAge Introduction Lecture: https://www.youtube.com/watch?si=ImDNb9kmMjA7rAqy&v=YTlr7vZVVIQ&feature=youtu.be

5. OMICmAge Testing: https://trudiagnostic.com/blogs/healthcare-partners/introducing-our-new-omicm-age-algorithm-report-suite