High Performance Longevity #220 5 Longevity Drivers That Actually Increase Lifespan by 500% | Dr. Zain Hakeem @ River Rock Medical
Jul 31, 2025
Dr. Zain Hakeem, a dual board-certified physician and creator of the Rx-Bayes app, delves into the core drivers of longevity. He argues that focusing on five key elements like VO2 max, social connections, and blood pressure is more beneficial than tracking countless biomarkers. Dr. Hakeem emphasizes the importance of quality relationships and the balance of exercise intensity for health. He also critiques the reliability of fitness devices and their metrics, advocating for scientifically rigorous methods to evaluate health interventions and enhance overall life quality.
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Prioritize Key Longevity Drivers
- Focus on just five key longevity drivers: VO2 max, strength, social connectedness, not smoking, and managing blood pressure.
- Prioritize interventions with the largest effect sizes to maximize lifespan impact.
Social Connections Drive Longevity
- Social connectedness, measured by quantity of contacts, predicts mortality more than loneliness feelings.
- Simply having one family member, one non-family friend, and community contact monthly greatly improves longevity.
Bradford Hill Criteria Explained
- The Bradford Hill criteria help infer causation from correlational data when randomized trials aren't possible.
- Strength of effect is the most reliable criterion; large mortality effects strongly indicate causality.
