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The Oprah Podcast

Weight Loss and GLP-1 Meds with Dr. Ania Jastreboff

Jan 14, 2025
Dr. Ania Jastreboff, an endocrinologist and GLP-1 medication expert from Yale, dives into the complex biology of obesity and the revolutionary role of medications like Ozempic and Wegovy. She explains why some struggle to lose weight and why obesity is a disease requiring more than willpower. Personal stories highlight transformative journeys with these medications, addressing misconceptions and stigma surrounding weight loss treatments. The conversation advocates for a compassionate approach to obesity management and emphasizes the importance of continuous support and understanding.
58:24

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Quick takeaways

  • Obesity is a disease influenced by biological factors, necessitating a shift in societal understanding away from personal choice blame.
  • GLP-1 medications like Ozempic effectively interact with brain receptors to help regulate hunger and promote lasting weight loss.

Deep dives

Understanding Obesity as a Disease

Obesity is recognized as a disease that is influenced by biological factors rather than a matter of personal choice. Two-thirds of Americans and nearly half of the global population face obesity, highlighting the need to understand the biological mechanisms at play. It is crucial to reevaluate the definitions of obesity and overweight, as traditional metrics like BMI may not effectively capture the complexity of the issue. The conversation revolves around how obesity impacts overall health and emphasizes the importance of treating obesity as a disease rather than merely focusing on weight loss.

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