The Optispan Podcast with Matt Kaeberlein 6 Months on TRT Changed My Body (THIS Is My Takeaway)
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Dec 13, 2025 In this engaging discussion, Matt shares his transformative experience on TRT, revealing weight gains and enhanced physique. He debates the merits of rapamycin versus fasting for longevity and tackles misconceptions about microplastics. Matt’s 4:30 AM wake-up routine enhances his productivity, and he reflects on the benefits of hyperbaric oxygen therapy. He also dives into bloodwork changes he's noted during TRT, including HDL levels. Plus, updates on his upcoming books spark curiosity—packed with practical health insights!
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Reluctance Before Starting TRT
- Matt admits he resisted starting testosterone because it felt like a lifelong commitment.
- He tried supplements and lifestyle changes first before confirming he was testosterone deficient.
Don't Chase Every New Intervention
- Pay attention to new data but don't switch interventions based on hype or absence of evidence.
- Avoid following people who constantly jump between interventions without conviction.
Rapamycin And Circadian Effects Are Unclear
- There is little human evidence that rapamycin meaningfully disrupts circadian rhythms or sleep.
- Animal data suggest rapamycin may improve age-related circadian decline, but human data are lacking.
