

312 | Thomas Levenson on the Mutual History of Humans and Germs
82 snips Apr 21, 2025
In this enlightening conversation, Thomas Levenson, a science writing professor at MIT, dives into the captivating journey of germ theory. He discusses how early microscopists like Anton van Leeuwenhoek laid the groundwork for modern microbiology, despite societal skepticism. The shift from miasmas to microbes in understanding disease is fascinating, especially in light of historical events like the Great Plague. Levenson also highlights the critical role of scientists like Semmelweis, and the ongoing public health challenges we face today in managing infectious diseases.
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Old Diseases Still Lurk
- All major historical infectious diseases still exist except smallpox, which is eradicated since 1980.
- Some, like tuberculosis and polio, remain deadly threats worldwide despite modern medicine.
Disease Theories Before Germs
- Prevailing disease theories emphasized bodily imbalances and miasma, offering coherent explanations before germ theory.
- The idea of invisible microbial agents causing disease was not necessary or compelling before the 19th century.
Cotton Mather's Inoculation Fight
- Cotton Mather promoted smallpox inoculation in 1721 Boston despite facing fierce opposition and even assassination attempts.
- His efforts saved lives but were resented by established medical professionals and clergy.