
Sean Carroll's Mindscape: Science, Society, Philosophy, Culture, Arts, and Ideas
Ever wanted to know how music affects your brain, what quantum mechanics really is, or how black holes work? Do you wonder why you get emotional each time you see a certain movie, or how on earth video games are designed? Then you’ve come to the right place. Each week, Sean Carroll will host conversations with some of the most interesting thinkers in the world. From neuroscientists and engineers to authors and television producers, Sean and his guests talk about the biggest ideas in science, philosophy, culture and much more.
Latest episodes

85 snips
Jun 2, 2025 • 3h 23min
AMA | June 2025
June 2025 brings intriguing discussions about effective hiring practices and the importance of financial literacy for kids. Listeners explore the intersection of scientific inquiry and philosophy at an upcoming symposium. Insightful reflections on the balance between common sense and scientific truth highlight misconceptions in reasoning. The podcast also critiques the Electoral College while examining complex topics like quantum mechanics and the implications for life in extreme environments. Additionally, the challenges of AI, creativity, and the nuances of consciousness add depth to the conversation.

72 snips
May 26, 2025 • 1h 29min
316 | Niayesh Afshordi and Phil Halper
Niayesh Afshordi, a physics and astronomy professor, and Phil Halper, a noted science communicator, dive into the mysteries of the universe and its origins. They discuss the complexities and misconceptions surrounding the Big Bang, the integration of quantum mechanics with general relativity, and exciting pre-Big Bang theories. The duo also explores innovative ideas in cosmology, such as cyclic and ekpyrotic models, and ponder entropy's role in cosmic evolution. Along the way, they challenge existing paradigms and encourage curiosity in scientific exploration.

155 snips
May 19, 2025 • 1h 29min
315 | Branden Fitelson on the Logic and Use of Probability
Branden Fitelson, a Distinguished Professor of Philosophy at Northeastern University, dives into the intricate world of probability and its significance in scientific inquiry. He discusses how understanding probability can help validate our scientific beliefs, distinguishing between inductive and deductive reasoning. Fitelson also explores the challenges of confirmation, including the Raven paradox and biases like the conjunction fallacy. He emphasizes the critical role of prior beliefs in shaping scientific evidence, especially in fields like particle physics.

91 snips
May 12, 2025 • 1h 9min
314 | Karen Lloyd on the Deep Underground Biosphere
Join Karen Lloyd, a microbial biogeochemist at USC and author of 'Intraterrestrials', as she unveils the secrets of Earth’s underground biosphere. Discover how resilient microbes survive in extreme conditions by tapping into electrons and ancient water sources. Explore the implications for life’s origins and the potential for extraterrestrial organisms. Lloyd also discusses groundbreaking advances in understanding the adaptations of these extremophiles and their interconnectedness with Earth’s ecosystems, challenging our traditional perspectives on life.

170 snips
May 5, 2025 • 1h 12min
313 | Eric Topol on the Changing Face of Medicine and Aging
In this engaging discussion, Eric Topol, a leading medical researcher and cardiologist, dives into the intersection of artificial intelligence and medicine. He explains how AI is revolutionizing diagnostics, often surpassing human doctors in accuracy. Topol offers insights into healthy aging, sharing actionable tips for maintaining vitality in later years. The conversation also highlights the importance of personalized healthcare, the connection between mental health and technology, and the growing challenges posed by the anti-aging industry.

116 snips
Apr 28, 2025 • 3h 38min
AMA | May 2025
In a heartfelt Ask Me Anything session, questions reveal stories of hope, like Puck the Cat's adoption journey. The blend of science fiction and AI sparks discussions on creativity and existential musings. The complexities of consciousness are challenged through physicalism and emergentism, while cosmology shines light on dark matter and the expanding universe. Topics range from visa injustices for international students to the balance of humor in speeches, all while emphasizing the importance of civic engagement and moral responsibilities in science.

82 snips
Apr 21, 2025 • 1h 31min
312 | Thomas Levenson on the Mutual History of Humans and Germs
In this enlightening conversation, Thomas Levenson, a science writing professor at MIT, dives into the captivating journey of germ theory. He discusses how early microscopists like Anton van Leeuwenhoek laid the groundwork for modern microbiology, despite societal skepticism. The shift from miasmas to microbes in understanding disease is fascinating, especially in light of historical events like the Great Plague. Levenson also highlights the critical role of scientists like Semmelweis, and the ongoing public health challenges we face today in managing infectious diseases.

119 snips
Apr 14, 2025 • 1h 10min
311 | Annaka Harris on Whether Consciousness is Fundamental
Annaka Harris, author of 'Conscious: A Brief Guide to the Fundamental Mystery of the Mind,' dives into the profound intricacies of consciousness. She explores whether consciousness is a product of brain activity or a fundamental aspect of reality. The conversation touches on split-brain research, the relationship between memory and self, and even questions the potential for AI consciousness. Harris advocates for open dialogue in understanding these complex ideas, bridging neuroscience and philosophy to illuminate the mysteries of the mind.

65 snips
Apr 7, 2025 • 3h 30min
AMA | April 2025
In this engaging AMA session, the speaker tackles pressing issues like government tariffs and civil liberties, spotlighting a student's troubling arrest by ICE. The discussion dives into quantum mechanics and its implications for understanding reality, alongside reflections on mental health accessibility. Voter rights, the complexities of democracy in the AI age, and the interplay between science and personal belief systems are thoughtfully explored. The conversation balances serious topics with listener questions, creating a rich tapestry of insight and inquiry.

105 snips
Mar 31, 2025 • 1h 26min
310 | Marc Kamionkowski on Dark Energy and Cosmic Anomalies
Marc Kamionkowski, a leading cosmologist at Johns Hopkins University, dives into the intriguing realm of dark energy and cosmic anomalies. He discusses the shocking 1998 discovery that the universe is accelerating, exploring the implications of the cosmological constant and its puzzlingly small value. Kamionkowski shares insights on the Hubble tension—discrepancies in the universe's expansion rates—and the potential for dark energy to vary over time. Their conversation showcases the ongoing battle to decode the universe's mysteries through collaborative scientific efforts.