The mindbodygreen Podcast 632: The science of skin aging & how to slow it down | Saranya Wyles, M.D., Ph.D.
Jan 11, 2026
Dr. Saranya Wyles, a leading dermatologist and regenerative medicine scientist at the Mayo Clinic, discusses the skin's role as a visible indicator of internal aging. She explains the five pillars of skin longevity: sleep, diet, exercise, stress management, and topicals. Wyles emphasizes the importance of a Mediterranean diet, effective sunscreen, and innovative treatments like lasers to rejuvenate skin. She even connects skin health to cognitive function, revealing fascinating insights into how cellular aging can impact the mind.
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Skin As A Window Into Systemic Aging
- Skin is our most visible biomarker of systemic aging and reflects internal health changes.
- Saranya Wyles, MD explains the skin's structure and function reveal systemic aging processes.
Melanocyte Loss Drives Visible Aging
- Skin aging shows structural (pigment loss, dyspigmentation) and functional decline (weaker UV defense).
- Melanocyte loss with each decade reduces pigment and UV protection, causing visible damage.
The Damage From Senescent ‘Zombie’ Cells
- Senescent 'zombie' cells accumulate when immune clearance slows and release harmful signals.
- These cells disrupt skin homeostasis and contribute to systemic inflammation and aging.