The potential of ketogenic diets and time-restricted feeding in preventing age-related cognitive decline.
The use of unique behavioral tests to assess age-related cognitive impairments in rodents.
The cognitive benefits of time-restricted feeding and the associated alterations in the gut microbiome.
Deep dives
Research focus on metabolic interventions for age-related cognitive decline
Dr. Abby Hernandez discusses her research on the potential of ketogenic diets and time-restricted feeding in preventing age-related cognitive decline. She explores the gut-brain axis and the intersection of basic biology, neuroscience, and peripheral metabolism to find ways to maintain or improve cognitive function in aging individuals.
Innovative behavioral tests in rodents to assess cognitive decline
Dr. Hernandez describes the unique behavioral tests conducted on rodents to assess age-related cognitive impairments. These tests include tasks related to working memory, spatial navigation, and object recognition. By analyzing the rodents' performance, she examines the selective vulnerability of brain regions such as the hippocampus and prefrontal cortex.
Alterations in neurotransmitters and metabolic flexibility in the aging brain
Dr. Hernandez investigates changes in neurotransmitters and metabolic flexibility in the aging brain. She highlights the impaired glucose utilization in the aged brain and the potential of utilizing alternative energy sources such as ketones. She also discusses the upregulation of glutamate and GABAergic signaling potential in response to a ketogenic diet.
Impact of time-restricted feeding on cognition and gut microbiome
Dr. Hernandez presents her findings on the cognitive benefits of time-restricted feeding in rodents. She explains the positive effects observed in cognitive performance and the alterations in the gut microbiome associated with improved cognition. These changes involve the upregulation of TCA cycle genes and specific gut microbes related to metabolic functionality.
Future directions: Targeting peripheral systems for cognitive preservation
Dr. Hernandez shares her plans for future research, aiming to merge her knowledge of neurobiology and cognitive function with peripheral systems, such as the gut microbiome and glucose metabolism. She discusses the possibility of genetically modified probiotics to mimic the effects of metabolic interventions and explore potential therapies for age-related cognitive decline.
This week’s episode of The Metabolic Link features an illuminating conversation between our host Dominic D’Agostino, PhD, and Dr. Abbi Hernandez, an assistant professor at the University of Alabama at Birmingham.
Dr. Hernandez received her PhD from the University of Florida, where she studied age and diet related changes in neurological function and cognitive health. Her research has focused on investigating the potential of ketogenic diets and time-restricted feeding for preventing age-related cognitive decline. Recently, she has been exploring the gut-brain axis.
In this episode, we cover:
The importance of the hippocampus for learning, memory, and cognition
Innovative rodent behavioral tests used to identify age-related cognitive impairments
Metabolic flexibility in the aging brain and the role of ketones
How time-restricted feeding alters the gut microbiome and cognitive performance
Future research directions on alternative brain fuels like lactate
Exploring the possibility of using probiotics to mimic the effects of ketosis on the brain
Dr. Hernandez will also be a speaker at Metabolic Health Summit 2024! Secure your spot here! Early bird pricing runs through October 1st and then it's gone for good!
In every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!
Please keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.
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