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Mayo Clinic Talks

Rheumatology Edition | What Everyone Should Know About Gout

Jan 9, 2024
Join rheumatologists Lynne S. Peterson, M.D., and Clement J. Michet JR, M.D., as they dive into the painful world of gout. Discover the tricky symptoms and cutting-edge diagnostic tests that can clarify this condition. They discuss effective management strategies and the importance of medication alongside dietary changes. Learn about recent treatment innovations, including the latest guidelines and emerging therapies. With patient education at the forefront, this conversation unveils the crucial aspects of living with and managing gout.
28:42

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Quick takeaways

  • Gout typically results from monosodium urate crystal deposition, causing severe pain during acute attacks and requiring effective management strategies.
  • Diagnosis involves a classic presentation and may need joint aspiration, emphasizing the importance of both acute care and long-term prevention.

Deep dives

Understanding Gout and Its Pathophysiology

Gout is primarily characterized by the deposition of monosodium urate crystals in joints, often resulting in severe pain, particularly in the big toe. This condition arises from increased uric acid levels due to either overproduction or under-excretion, with the latter accounting for 90% of cases. Risk factors include family history, metabolic syndrome, and certain medications, with women typically being less affected until menopause. Acute attacks often occur at night due to temperature changes and fluid shifts in the body, leading to a rapid onset of pain.

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