The Tim Ferriss Show

#193: My Life Extension Pilgrimage to Easter Island

Oct 20, 2016
Former ultra-endurance athlete Peter Attia, go-to doctor for all things performance and longevity, joins the show with other experts to discuss rapamycin's potential in increasing lifespan, metabolism and nutrient sensing, intermittent dosing, and the comparison between metformin and rapamycin. Other topics include intravenous vitamin C, the importance of confidence in writing, data aesthetics, extending human lifespan, and personal anecdotes about their journey and struggles. They also explore the findings on Easter Island and the significance of mutual benefit in relationships.
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INSIGHT

Rapamycin and Metabolism

  • Rapamycin targets mTOR, a central regulator of metabolism involved in growth and nutrient sensing.
  • Its inhibition extends lifespan and healthspan in various organisms, making it a key target in longevity studies.
INSIGHT

Rapamycin Extends Lifespan

  • Inhibiting mTOR with rapamycin experimentally extends lifespan up to 30% in worms and mice.
  • Such effects suggest potential translational impact on healthspan and longevity in humans.
INSIGHT

Reactive Oxygen Species Are Signaling Molecules

  • Reactive oxygen species (ROS) like hydrogen peroxide serve crucial signaling roles at low levels.
  • Blanket antioxidant supplementation can disrupt these beneficial roles, possibly impairing health.
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