The Future of Aging with Aubrey de Grey

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Apr 15, 2025

Aubrey de Grey, a leading biomedical gerontologist and founder of the LEV Foundation, discusses his pioneering work aimed at reversing aging. He explains why aging may be more easily reversible than previously thought. The conversation dives into major players in longevity research like HEvolution and Calico, revealing insights about their differing approaches. Regulatory innovations, such as Montana's Right to Try legislation, are highlighted as crucial for accelerating advancements. De Grey also shares details about a groundbreaking study with middle-aged mice targeting significant lifespan extension.

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INSIGHT

Saudi Investment in Longevity

The Saudi royal family's plan to invest $1 billion annually for 20 years in longevity research is unprecedented.
Progress has been slow but foundational groundwork and strong leadership promise major future impact.

INSIGHT

Longevity Company Differentiation

Calico by Google has struggled due to poor pipeline and lack of translation to products.
Retro Biosciences, led by Joe Betts-Lacroix and funded by Sam Altman, shows the most promise due to focused leadership and strategy.

INSIGHT

Prospera's Regulatory Innovation

Prospera in Honduras is a special economic zone designed to expedite biomedical innovation with flexible regulations.
It could become the global hub for medical tourism and accelerate drug development by bypassing slow traditional approval processes.

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Dr. Aubrey de Grey reveals why reversing aging may be easier than slowing it down in this mind-expanding conversation that challenges conventional wisdom about human longevity. The renowned biomedical gerontologist outlines his damage repair approach that's gaining mainstream scientific acceptance after initial skepticism.

The financial landscape of longevity research has dramatically transformed, with billions flowing into the space. Dr. de Grey provides an insider's assessment of major players including HEvolution (Saudi-backed), Altos Labs (Bezos-funded), Calico (Google-funded) and Retro Biosciences (Sam Altman's venture), offering candid insights about which approaches show the most promise and why Google's Calico has struggled despite substantial resources.

Regulatory innovation emerges as a crucial accelerator for progress. Montana's groundbreaking expansion of Right to Try legislation now allows anyone to access treatments that have passed FDA safety trials, while special economic zones like Prospera in Honduras are creating regulatory environments specifically designed for biomedical innovation. These developments could create the competitive pressure needed to modernize traditional regulatory structures worldwide.

At the LEV Foundation, Dr. de Grey is conducting a thousand-mouse study combining four different damage repair interventions in middle-aged mice, aiming for a full year of life extension—far beyond the four months typically achieved. Unlike conventional approaches that rely on dietary modifications, this ambitious project incorporates advanced cell and gene therapies that target multiple forms of age-related damage simultaneously.

Looking forward, Dr. de Grey offers his characteristic probabilistic prediction: a 50-50 chance of reaching "longevity escape velocity" within 12-15 years. This would enable taking 60-year-olds and rejuvenating them enough that they wouldn't be biologically 60 again for another 20 years, during which time further advances would enable additional rejuvenation cycles—potentially creating open-ended healthy lifespans for many alive today.

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