
The Dr. Hyman Show Why Small Intestinal Bacterial Overgrowth (SIBO) Rarely Occurs On Its Own
May 14, 2021
George Papanicolaou, a family medicine physician and functional medicine expert, discusses the complexities of Small Intestinal Bacterial Overgrowth (SIBO). He explains how SIBO often coexists with various health issues and the critical role of gut bacteria in overall wellness. The conversation highlights diagnostic techniques, including breath tests, and underscores the gut-brain connection. Papanicolaou advocates for a holistic treatment approach, blending lifestyle and dietary changes for better gut health and improved mental well-being.
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SIBO Symptoms and Impact
- SIBO, or small intestinal bacterial overgrowth, occurs when bacteria grow in the small intestine, causing discomfort.
- Symptoms include bloating, distension, incomplete bowel movements, fatigue, depression, anxiety, and brain fog.
SIBO and the Food Baby Analogy
- SIBO is like fermenting food in the wrong place (Maine instead of Florida).
- This causes gas, discomfort, and impacts nutrition, inflammation, leading to a gut-brain connection and affecting mental health.
SIBO and the Microbiome
- SIBO rarely occurs alone due to its connection to the gut microbiome.
- A disrupted microbiome affects food processing, absorption, and immune responses, leading to leaky gut and food sensitivities.

