MTOR Unveiled Part 2: Protein, MTOR, and Muscle Growth
Aug 23, 2023
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Discover the science behind muscle growth, protein synthesis, and MTOR activation. Learn how to maximize fasting without muscle loss, the impact of protein intake on MTOR and longevity, and the intricate relationships between variables in medicine. Unveil the complexity of protein and muscle growth, and explore the benefits and considerations of a plant-based protein diet.
Activation of mTOR is crucial for muscle growth and can be achieved through factors such as protein intake, leucine, insulin, and glucose.
The impact of protein on longevity varies depending on age, with higher protein intake being beneficial for individuals over 65, but potentially detrimental for those below 65, especially from animal sources.
Deep dives
Protein intake and muscle development
Protein intake plays a crucial role in muscle development and synthesis. Activation of the anabolic signaling pathway, mTOR, is essential for muscle growth. Factors such as eating amino acids, particularly leucine, insulin-like growth factor, cellular stress, insulin, and glucose can activate mTOR. Conversely, glucagon and cortisol can inhibit mTOR. Activation of mTOR leads to increased protein synthesis, hypertrophy of muscle cells, activation of satellite cells for muscle repair and growth, and inhibition of muscle protein breakdown. Understanding the connection between protein intake and muscle development is important for optimizing exercise and resistance training.
Protein intake and longevity
The relationship between protein intake and longevity is complex. There is conflicting evidence on whether a high protein diet is beneficial or detrimental to longevity. Some studies suggest that higher protein intake, particularly from animal sources, may increase the risk of mortality, cardiovascular disease, and diabetes, especially in individuals below 65 years old. However, it is important to consider individual factors such as genetics, metabolic health, and the source of protein. Plant-based protein intake appears to have a more positive effect on longevity. More research is needed to understand the specific interactions between protein intake, genetics, and health outcomes.
The impact of protein on different age groups
The impact of protein on longevity seems to vary depending on age. For individuals over 65 years old, higher protein intake, regardless of the source, is associated with a reduction in mortality. Maintaining muscle mass and preventing age-related muscle loss, known as sarcopenia, become more important as individuals age. Conversely, for individuals below 65 years old, higher protein intake, especially from animal sources, may be associated with increased mortality, cardiovascular disease risk, and diabetes. It is crucial to consider age-related differences and individual factors when determining the optimal protein intake.
Individualized approach to protein intake
Given the complexity of the relationship between protein intake and health outcomes, an individualized approach is essential. Factors such as genetic predispositions, metabolic health, and personal goals need to be considered. While there is a general indication that higher protein intake from plant sources is beneficial, determining the appropriate protein intake requires a personalized assessment. Working with a healthcare professional who can evaluate genetics, biomarkers, and lifestyle factors can help individuals determine the optimal protein intake for their specific circumstances.
Join Doctors Mike Mallin and Mike Stone as they delve into the science of muscle growth, protein synthesis, and MTOR. Discover how protein synthesis repairs and builds muscles, learn how to activate MTOR for optimal gains, and understand the difference between anabolic and catabolic processes. Get practical tips on maximizing fasting without muscle loss and explore the impact of protein intake on MTOR and longevity.
Whether you're an athlete or fitness enthusiast, this episode provides essential knowledge to unlock your muscle-building potential.