545- The Surprising Association Between ADHD & Inflammatory Disorders
Mar 4, 2025
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In this discussion, psychiatrist James Kustow delves into the surprising links between ADHD and inflammatory conditions like allergies and autoimmunity. He reveals how neuroinflammation could affect mental health and highlights the significance of connective tissue disorders. Kustow emphasizes the impact of estrogen on ADHD symptoms in women and shares dietary strategies to support gut health and ADHD management. This engaging conversation frames ADHD as a complex interplay of mental and physical health factors, advocating for a holistic approach.
ADHD is increasingly seen as a systemic issue influenced by inflammation, linking it to various physical health conditions like allergies and autoimmune disorders.
The relationship between ADHD and hypermobility suggests that addressing physical manifestations may improve overall treatment approaches and symptom management for individuals with ADHD.
Deep dives
Connection Between ADHD and Inflammation
A strong link exists between ADHD and inflammation, suggesting ADHD is not solely a brain disorder but may also have significant bodily influences. Studies indicate that individuals with ADHD often experience higher rates of various inflammatory conditions such as allergies and autoimmune disorders. For instance, maternal inflammation during pregnancy has been shown to increase ADHD risk in children. This emerging understanding posits that ADHD could represent a broader systemic issue rather than a mere neurological dysfunction.
Neuroinflammatory Hypothesis of ADHD
The neuroinflammatory hypothesis of ADHD proposes that inflammatory processes are central to the presentation of ADHD symptoms. Evidence indicates that inflammatory markers are often elevated in those diagnosed with ADHD, connecting the condition to various physical health problems. Additionally, the hypothesis suggests that issues like gut dysbiosis and autoimmune reactions may exacerbate ADHD symptoms. It emphasizes the necessity for research into the underlying mechanisms linking inflammation and ADHD, particularly how they could affect neurodevelopment.
Impact of Lifestyle and Environment
Lifestyle choices and environmental factors play a crucial role in managing ADHD symptoms and their inflammatory underpinnings. Factors like diet, stress, exposure to toxins, and even hormonal changes can influence inflammatory responses and ADHD symptom severity. Adopting a balanced diet, particularly one rich in anti-inflammatory foods like those found in the Mediterranean diet, can be beneficial. Additionally, awareness of personal triggers, such as food intolerances or environmental hazards like mold, is vital in reducing inflammation and improving overall health.
Hypermobility and ADHD Correlation
Hypermobility appears to be significantly correlated with ADHD, presenting another layer of complexity in understanding the condition. Individuals with ADHD often exhibit higher rates of joint hypermobility, which can be related to connective tissue problems affecting overall health. This correlation suggests that addressing hypermobility may help in managing ADHD symptoms, as it can also be linked to autonomic dysfunction and inflammation. By focusing on this connection, clinicians may develop more holistic treatment approaches that encompass both ADHD and its physical manifestations.
Join James Kustow, BMBS, MRCPsych, to learn about the emerging research that may explain ADHD’s unexpected associations with inflammatory conditions like allergy and autoimmunity — and a surprisingly strong link with hypermobility syndrome.
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