What does "mad as a hatter" make you think of in medicine? In this episode we go over the nuances of a medical emergency- TCA overdose! Written by Dr. Leah Kosyakovsky (Internal medicine resident at the time of writing, now cardiology fellow). Reviewed by Dr. Pete Wu (General internal medicine and pharmacology/toxicology) and Dr. David Juurlink (General internal medicine and pharmacology/toxicology). Infographic by Dr. Shannon Gui (Internal Medicine Resident). Produced by Dr. Nafis Houssain (Intern Medicine Resident)