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124. Mad Hatter- TCA Overdose

The Intern At Work: Internal Medicine

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How Much Teses Are Needed to Cause an Overdose?

The first ca, mipromine, was derived from the anti psychotic pro methasine for this purpose. While mi promine was ineffective in relieving psychotic symptoms and patients with scitzophenia, it was incidentally noticed to be very effective in alleviating depression. Mipromine was approved as the eighti depressent in 19 59 by us fda. And thus the t c a class was born. Tcs also act as sodium and calcium channel blockers at high doses. The inhibition of nora epinefron and seratonan re up take are likely the most important mechanism of action,. whereas the latter three effects likely contribute to the most important side effects.

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