JAMA Clinical Reviews Treatment and Management of Osteoporosis
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Jun 30, 2025 Suzanne Morin, a Professor of Medicine at McGill University and expert on osteoporosis, joins JAMA Deputy Editor Mary McDermott to discuss this critical health issue. They delve into the alarming statistics, noting that 1 in 3 women and 1 in 5 men over 50 experience osteoporotic fractures. Risk factors and screening are vital, especially for those with prior fractures. Morin also sheds light on treatment options, including medications like bisphosphonates, and the emerging anabolic therapies that could significantly improve outcomes for high-risk patients.
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Osteoporosis Pathophysiology
- Osteoporosis results from low bone mass and deterioration causing fractures.
- It mainly develops after 50 due to imbalanced bone formation and resorption.
Osteoporosis Prevalence and Risk
- Osteoporosis affects 54 million Americans and over 200 million globally.
- One in three women and one in five men over 50 will experience fracture.
Key Osteoporosis Risk Factors
- Screen for osteoporosis in people with risk factors like chronic inflammation or corticosteroid use.
- Include low body weight and sedentary lifestyle as additional risks to consider.