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The Immunology Podcast

Ep. 9: “Lymphocyte Activation” Featuring Dr. Marc Jenkins

Jul 20, 2021
Explore the intricate world of lymphocyte activation with Dr. Marc Jenkins, focusing on CD4+ T and B cell activation. Topics cover metabolic control of T follicular helper cells, the impact of HIV treatment on microbiome, rare side effects of COVID-19 vaccines, the role of CD28 activation in T cell response, and the challenges in studying CD4 T cells. Dr. Jenkins also shares insights into TCR signaling, T cell differentiation, and his outdoor adventures in fishing and biking.
01:15:57

Episode guests

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Quick takeaways

  • CD28 signaling enhances TCR activation and prevents T cell anergy.
  • IL-2 receptor signaling plays a crucial role in early T cell fate determination, influencing TH1 differentiation.

Deep dives

CD28 Activation and TCR Signaling in T Cell Activation

CD28 signaling enhances TCR activation and prevents T cell anergy. Early research showed that TCR stimulation alone is insufficient for full T cell activation. CD28 costimulatory signal synergizes with TCR signaling to activate T cells. IL-2 receptor signaling through STAT-5 influences early T cell fate determination.

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