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Ep. 9: “Lymphocyte Activation” Featuring Dr. Marc Jenkins

The Immunology Podcast

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Exploring T Cell Activation and Tetramerology in Immunology Research

The chapter delves into the state of T cell activation in 1992, looking at the importance of CD28 signaling as a second signal and the challenges in studying CD4 T cells compared to CD8 T cells. It discusses the complexities and advancements in creating tetramers for CD4 T cells, including the development of engineered tetramers through molecular evolution techniques to enhance the detection of lower affinity TCRs, providing insights for future experiments in T cell activation.

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