Freely Filtered 040: Double CLICK for BP control in CKD stage 4

The Filtrate:

Joel Topf

Swapnil Hiremath

Jennie Lin (who was only there because her plans got boxed by covid)

Jordy Cohen

Josh Waitzman

Special Guest:

Rajiv Agarwal (@AgarwalRajivMD)

Editor:

Joel Topf

Show Notes:

NephJC discussion of CLICK: http://www.nephjc.com/news/click4chlorthalidone

CLICK Visual abstract: http://www.nephjc.com/news/2021/12/7/the-click-visual-abstract

Hawthorne effect: https://en.wikipedia.org/wiki/Hawthorne_effect

A nice discussion run in periods in clinical trials: http://www.nephjc.com/news/run-in-period

The ABCD trial Agarwal used to describe the need for a beta blocker to enroll in the trial, but it looks like a review article https://pubmed.ncbi.nlm.nih.gov/12574784/

Canadian trial showing that atenolol did as well as evidence based beta blockers: https://pubmed.ncbi.nlm.nih.gov/31495887/ Associated editorial by Agarwal: https://pubmed.ncbi.nlm.nih.gov/31578572/

Meta-analysis of dose-response relationships for hydrochlorothiazide, chlorthalidone, and bendroflumethiazide on blood pressure, serum potassium, and urate by Mark A Peterzan https://pubmed.ncbi.nlm.nih.gov/22547443/

HCTZ vs Chlorthalidone compete to the death: VA CSP Study No. 597: Diuretic Comparison Project https://www.research.va.gov/programs/csp/597/default.cfm

Effectiveness versus Efficacy Trials: https://www.ncbi.nlm.nih.gov/books/NBK44024/

Foundation on Apple TV+: https://www.indiewire.com/2021/09/foundation-review-apple-tv-plus-sci-fi-adaptation-1234666972/

The Expanse on Amazon Prime: https://en.wikipedia.org/wiki/The_Expanse_(TV_series)

The Beatles: Get Back on Disney+: https://en.wikipedia.org/wiki/The_Beatles:_Get_Back

School of chocolate on Netflix: https://www.themarysue.com/school-of-chocolate/

And Just Like That... on Disney+: https://en.wikipedia.org/wiki/And_Just_Like_That...

Past-president of AHA forced to make a statement about the Sex and the City episode: https://twitter.com/NMCardioVasc/status/1471627453885997068 https://twitter.com/NMCardioVasc/status/1471817955344371717

Chris Noth is a bad guy and how Peloton dealt with this. https://variety.com/2021/digital/news/peloton-deletes-chris-noth-ad-sexual-assault-allegations-1235135264/

Apply for the NSMC Social Media Internship: https://www.nsmc.blog