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ACR Journals On Air

Calprotectin in Antiphospholipid Syndrome

Jul 23, 2024
Dr. Yu Zuo, a researcher at the University of Michigan, delves into the intriguing role of calprotectin in antiphospholipid syndrome (APS). He discusses how calprotectin could serve as a functional biomarker for APS thrombocytopenia, emphasizing its implications for patient outcomes. The conversation highlights the challenges in detecting this autoimmune disorder and the urgent need for better biomarkers. Zuo also reflects on his journey in medicine, influenced by pivotal mentorship, and addresses how COVID-19 reshaped research priorities in this field.
24:19

Episode guests

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Quick takeaways

  • Calprotectin's correlation with neutrophil counts and thrombocytopenia represents its potential as both a biomarker and a therapeutic target in APS management.
  • Ongoing research into calprotectin's mechanistic role may inform new strategies to enhance patient care in antiphospholipid syndrome complications.

Deep dives

Understanding Antiphospholipid Syndrome

Antiphospholipid syndrome (APS) is an autoimmune thrombo-inflammatory disorder characterized by a spectrum of clinical manifestations, including blood clotting complications and thrombocytopenia. Early diagnosis and personalized treatment are hampered by a lack of clinically actionable biomarkers for various symptoms associated with APS. Enhanced biomarkers are essential for timely detection of complications, allowing for improved risk assessment and management strategies for patients with APS. This progressive understanding is crucial for advancing therapeutic approaches to mitigate the effects of this complex disease.

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