Dr. Yu Zuo, a researcher at the University of Michigan, delves into the intriguing role of calprotectin in antiphospholipid syndrome (APS). He discusses how calprotectin could serve as a functional biomarker for APS thrombocytopenia, emphasizing its implications for patient outcomes. The conversation highlights the challenges in detecting this autoimmune disorder and the urgent need for better biomarkers. Zuo also reflects on his journey in medicine, influenced by pivotal mentorship, and addresses how COVID-19 reshaped research priorities in this field.