Dr. Matt and Dr. Mike's Medical Podcast Statins | Cholesterol Lowering Drugs
May 17, 2025
Dive into the world of statins and discover how these cholesterol-lowering drugs function and their various side effects. Learn about the fascinating journey of cholesterol, from its impact on heart health to its historical significance. Uncover the alarming effects of high cholesterol in children and the genetic factors involved. The evolution of statins is also explored, along with personal anecdotes on their complex therapy and potential side effects. Plus, discover how bile composition plays a crucial role in gut health!
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LDL and HDL Roles Explained
- LDLs (low-density lipoproteins) transport cholesterol and drop it off in tissues, potentially littering blood vessels causing problems.
- HDLs (high-density lipoproteins) act as recyclers, collecting excess cholesterol and returning it to the liver for reuse or disposal.
Statins Target Mevalonate Pathway
- Statins inhibit the HMG-CoA reductase enzyme in the mevalonate pathway, reducing cholesterol synthesis.
- This pathway also produces coenzyme Q10, linking statins to potential muscle side effects via energy metabolism.
Statin-Related Gastrointestinal Effects
- Expect gastrointestinal side effects like bloating or diarrhea when starting statins.
- These may arise from changes in bile acid composition caused by liver cholesterol modulation.