This podcast discusses the role of FODMAPs in irritable bowel syndrome; the presence of mucus in the stool and its relation to parasitic infections; the connection between cardio and muscle growth; the potential risks of microdosing psychedelics; and the reasons behind waking up at 3 am.
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Quick takeaways
Microdosing psychedelics may pose a risk of valvular heart disease due to their binding to serotonin 2B receptors.
Incorporating aerobic training before resistance training can support muscle growth and hypertrophy.
Nighttime awakenings can be caused by various factors, including sleep environment disturbances, pain, and sleep disorders, but can be improved through good sleep hygiene practices.
Deep dives
Microdosing and the Potential Risks of Valvular Heart Disease
Microdosing psychedelics, such as LSD and psilocybin, has gained popularity for its potential cognitive and mood-enhancing effects. However, a recent article highlights a theoretical concern that prolonged and repeated microdosing could lead to valvular heart disease (VHD). Some medications with high affinity for the serotonin 2B receptor, like MDMA, have been associated with VHD. Since psychedelics also bind to this receptor, regular microdosing could pose a similar risk. It is crucial to exercise caution and moderation when using psychedelics, understanding the potential risks involved.
The Connection between Cardio and Muscle Growth
The common belief that cardio hinders muscle growth may not be entirely accurate. A study has shown that incorporating aerobic training before resistance training can lead to greater muscle hypertrophy and satellite cell content. The increased capillary density resulting from aerobic training supports further muscle growth. This finding suggests that combining cardio with weight training can be beneficial for muscle development and overall fitness. Using blood flow restriction (BFR) training techniques can be an effective strategy for promoting capillary growth and maximizing the benefits of cardio and strength training.
Understanding Waking Up in the Wee Hours
Waking up in the middle of the night can be frustrating, and there are several possible explanations for this. Sleep environment disturbances, nighttime bathroom breaks, pain, neurological disorders, sleep disorders like sleep apnea, age-related changes in melatonin production and circadian rhythms, withdrawal from substances, and other factors can contribute to nighttime awakenings. Practicing good sleep hygiene, such as optimizing the sleep environment, avoiding caffeine or alcohol before bed, and maintaining a regular sleep schedule, can help improve sleep quality and reduce awakenings.
The Controversy Surrounding Gluten Restriction and Low FODMAP Diets
Many people mistakenly believe that gluten is the main cause of digestive issues like irritable bowel syndrome (IBS). However, research suggests that fermentable compounds called FODMAPs (fermentable oligosaccharides, disaccharides, monosaccharides, and polyols) present a greater problem for individuals with IBS. While those with celiac disease may benefit from gluten restriction, individuals with IBS should consider a low FODMAP diet, which involves reducing intake of certain fruits, grains, vegetables, and dairy products. Understanding the difference between gluten restriction and a low FODMAP diet can help individuals manage their digestive symptoms more effectively.
Strategies to Improve Sleep and Address Sleep Interruptions
Experiencing sleep interruptions like difficulty falling back asleep after waking up at night can be frustrating. Implementing strategies like maintaining a dark and quiet bedroom environment, avoiding heavy meals or stimulating substances before bed, engaging in regular exercise, and addressing potential sleep disorders such as sleep apnea or bladder issues can improve sleep quality and reduce sleep interruptions. Additionally, considering factors like melatonin supplementation, mouth or nose taping, and exploring spiritual interpretations of nighttime awakenings can be helpful in addressing sleep disturbances.
Guess what? That expensive parasite cleansing system that you are using might have something called Mimosa pudica in it. Basically, this ingredient makes a bunch of long mucus threads wind up in the toilet (which look like rope worms, but aren’t): What Are Rope Worms? Are They Even Real?...14:47
There is "compelling theoretical evidence to suggest prolonged and repeated microdosing may cause valvular heart disease (VHD), and only weak survey evidence that it provides the benefits microdosers typically seek, such as enhanced cognition, or relief from depression and anxiety": "Safety First: Potential Heart Health Risks of Microdosing" — risk is particularly associated with repeated microdosing over several years, attributed to the strong binding affinity of microdoses like LSD or psilocybin to the serotonin 2B receptor (5-HT2B)...29:55