What's The Juice cover image

What's The Juice

S5E13 Why Histamine Intolerance May Be at the Root of Your Unexplained Symptoms | Michelle Shapiro, RD

May 13, 2024
Functional dietitian Michelle Shapiro discusses histamine intolerance, the connection to MCAS, and the challenges of diagnosis. She shares her own journey with mysterious symptoms post-COVID and mold exposure, highlighting the immune system's role in overdrive. Topics include long COVID implications, the physical manifestations of histamine intolerance, and the interconnected nature of conditions like POTS and Ehlers-Danlos syndrome.
02:12:54

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Quick takeaways

  • Histamine intolerance symptoms include diverse issues like insomnia and acid reflux.
  • Stress and environmental changes can trigger hypersensitivity and mast cell activation.

Deep dives

Understanding Histamine Intolerance and MCAS Symptoms

Symptoms of histamine intolerance, also known as MCAS or mast cell activation syndrome, include a wide range of seemingly unrelated issues such as racing heart at night, extreme water retention, and paradoxical reactions to foods like tomatoes, citrus fruits, and bone broth. Additional symptoms consist of hives, splotchy rashes post-shower, dizziness, insomnia, depression, alternating gastrointestinal problems like diarrhea and constipation, and persistent nausea. These symptoms often appear in flares, leaving individuals feeling swollen, uncomfortable, and struggling with abnormal bodily functions.

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