The Peter Attia Drive

#27 - David Sinclair, Ph.D.: Slowing aging – sirtuins, NAD, and the epigenetics of aging

6 snips
Nov 5, 2018
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Episode notes
1
Introduction
00:00 • 2min
2
The French Paradox Has Been Sold
02:01 • 4min
3
Professor David Sainclair Interview
05:41 • 1min
4
I'm Really Excited to Be Able to Share That Science With Listeners
06:42 • 5min
5
The Only Jeans That Have Relevance to Aging and Longevity
11:15 • 2min
6
Lenny's Lost His Mind
13:03 • 3min
7
What We Didn't Know About Silencing Proteins
16:07 • 2min
8
Sirtuans and Dena Repair
18:33 • 2min
9
What Are the Younow Again?
20:38 • 5min
10
How Do You Get the Benefits of Calo Restrictions?
25:28 • 2min
11
Yeast and Coloric Restriction - What's the Teleologic Explanation?
27:38 • 2min
12
The Life Cycle of a Yeast Cell
29:56 • 2min
13
Sten Repair Ancous, Is It a Difficult Decision?
31:35 • 2min
14
How Does N a D Dependent Dasetles Work?
33:09 • 2min
15
How Do You Deplete an a D?
34:58 • 2min
16
The Mitacondrial Oasis
36:46 • 2min
17
Yeast Stress
38:37 • 3min
18
The Na D Synthesis Pathway in Yeast
41:07 • 2min
19
What Was the Gold Standard Prior to Sertuin Activity?
42:52 • 3min
20
Resveratrol and the Lifetime Penotype
46:09 • 2min
21
Are There Other Reasons Why Serto Won't Work?
48:27 • 2min
22
Dose of Resevetrol Is Energistic With Metforman
50:21 • 2min
23
The Effects of Resvertal on Mice Lives
52:25 • 2min
24
The Fat Solubility of Resverto
54:49 • 2min
25
Resvertol
56:38 • 2min
26
Do You Still Take Resverto?
59:08 • 2min
27
Is It a Good Idea to Add a Precursor to N a D?
01:01:36 • 2min
28
Is Lenny Vindicated for Finding That the Sortuans Are Important for Health?
01:03:33 • 2min
29
Do You Think Elysium Is Safe?
01:05:43 • 2min
30
Do You Have a Title for David's Book?
01:07:16 • 2min
31
The Difference Between N R and Nm N
01:09:00 • 2min
32
Is Mitacondrial N a D Increasing?
01:10:37 • 2min
33
Is Rapa Micein Tissue Specific?
01:12:31 • 2min
34
Is There a Male Fertility Opportunity?
01:14:59 • 2min
35
Is Your Name on Something?
01:16:50 • 2min
36
Life by Sciences
01:18:57 • 2min
37
The Genes of Old People and Old Animals Are Largely Intact
01:20:35 • 3min
38
Are We Going to See a Step Function Change in Human Longevity?
01:24:01 • 2min
39
How Do You Get the Cells to Remember to Access at the Right Time?
01:26:27 • 2min
40
Is There an Experiment That Could Accelerate Our Knowledge?
01:28:19 • 3min
41
The Combination, Youac Matrix?
01:31:10 • 2min
42
Are You Always Going Around?
01:33:00 • 3min
43
How Do You Communicate With People?
01:35:42 • 2min
44
How Did You Cope With the Half Life of Facts?
01:37:51 • 2min
45
The Podcast - The Nerd Sopari Podcast
01:39:40 • 2min