The Optispan Podcast with Matt Kaeberlein

“Zombie” Senescent cells may play HUGE role in LIVING LONGER, Here's How: | 22 - Natalia Mitin

Apr 10, 2024
Natalia Mitin, Co-founder and CEO of Sapere Bio, dives into the fascinating world of senescent cells—those zombie-like cells that stop dividing yet affect aging and health. She shares insights on measuring cellular senescence and introduces the groundbreaking Sapir-X test for evaluating biological age. Natalia discusses her off-label use of rapamycin, emphasizing careful monitoring and the complexities of immune health. With a background in cancer research, she also explores the potential of senolytic treatments and their implications for diseases like Alzheimer's.
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INSIGHT

Biological Risk Beats Chronological Age

  • Sapere Bio measures blood senescence and immune function to reveal individualized biological risk beyond chronological age.
  • Knowing a patient's biological state helps clinicians tailor treatments rather than treating by age alone.
INSIGHT

Two-Part Readout Reveals Mechanism

  • Sapir-X returns two linked measures: senescent cell load and an immune longevity score to show mechanism-specific changes.
  • This dual readout reveals whether interventions affect senescence, immune function, or both, enabling targeted follow-up.
ADVICE

Test Before, During, And After Interventions

  • Monitor multiple biomarkers longitudinally so you can tell which biological process an intervention changed.
  • Use that information to stop, continue, or pivot treatments based on measurable effect, not guesswork.
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