Oncotarget
Osteopontin Induces Mitochondrial Biogenesis in Deadherent Cancer Cells
Dec 14, 2023
Dr. Georg F. Weber, a researcher from the University of Cincinnati, talks about his research paper on 'Osteopontin induces mitochondrial biogenesis in deadherent cancer cells'. He discusses the unique metabolism of metastasizing cells and their preference for glycolysis. The chapter also explores the connection between mitochondrial activation and biogenesis in cancer cells, with a focus on the role of osteopontin. Additionally, peroxide production in cancer cells and its impact on cancer metastasis is discussed, revealing surprising findings about the involvement of mitochondrial decoupling and SLC7A11 channel.
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Quick takeaways
- Metastasizing cells rely on mitochondrial biogenesis for long-term survival and establishment in distant organs during cancer metastasis.
- The splice variant osteopontin C stimulates an increase in mitochondrial mass through a signaling cascade involving CD44 and SLC7A11, highlighting its role in promoting cancer metastasis.
Deep dives
Unique Metabolism of Metastasizing Cells
Metastasizing cells have a distinct metabolism that differs from primary tumors. While primary tumors preferentially use glycolysis for ATP generation, metastasizing cells activate oxidative phosphorylation by mitochondria. This energy production shift is crucial for the survival and establishment of metastatic colonies in distant organs. Over short timeframes, oxidative phosphorylation and ATP generation are prominent, while over longer timeframes, mitochondrial biogenesis becomes a pronounced feature. The connection between mitochondrial activation and biogenesis in metastasizing cells has been confirmed, showcasing their importance in cancer metastasis.
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