The Dr. Gundry Podcast Top 3 Spermidine Benefits You Never Knew - Dr. G's Quick Health Tip | EP 386.B
Jan 15, 2026
Explore the intriguing benefits of spermidine and its essential role in autophagy, your body's natural cleansing process. Discover how this compound can enhance longevity and cellular health. Delve into its biological origins and how it can improve brain function and mitochondrial health. Learn about the best dietary sources, safety considerations, and even its potential for stimulating hair growth. Uncover practical ways to incorporate spermidine into your routine for optimal well-being!
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Spermidine Activates Cellular Recycling
- Spermidine is a natural polyamine that robustly induces autophagy without fasting.
- It works by inhibiting acetyltransferase and mTOR while activating the AMPK pathway to trigger cellular recycling.
Yeast Studies Clarify Spermidine Mechanism
- Yeast studies linked spermidine to upregulation of autophagy genes and increased lifespan.
- The lifespan benefit disappeared when yeast lacked autophagy genes, supporting a direct autophagy mechanism.
Boosting Brain Mitochondria And Energy
- Spermidine-induced autophagy improves mitochondrial function and produces mitophagy in the brain.
- It crosses the blood-brain barrier and may increase ATP production and help reverse cognitive decline.
