AI Snips
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Evolution and Aging
- Aging must be viewed through an evolutionary lens.
- Humans rarely lived past 40-45 during early evolution, so natural selection didn't prioritize longevity.
Cellular Senescence and Aging
- Cellular senescence, while beneficial in youth for cancer protection and embryonic development, can drive age-related diseases.
- Intervening in this process requires caution due to its diverse roles.
Senescent Cell Behavior
- Senescent cells cease dividing, resist death, and secrete molecules impacting surrounding cells.
- This secretion can have positive effects like wound healing but also negative ones like promoting inflammation and cancer.