The Metabolic Classroom with Dr. Ben Bikman The Skinny on Fat: Sex and Fat Metabolism
Mar 21, 2024
Dr. Ben Bikman, an expert in fat metabolism and endocrine organs, discusses the role of fat tissue as an endocrine organ, focusing on hormone production and regulation. He explores sex-specific differences in fat distribution, the impact of menopause on fat tissue and hormonal changes, leptin's role in appetite regulation, and the effects of other hormones on metabolism and fat cell size. The podcast delves into the production of T3 in brown adipose tissue and its metabolic effects.
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Fat Tissue: An Endocrine Organ
- Fat tissue isn't just an inert energy store; it's an endocrine organ, producing hormones with metabolic effects.
- These hormones impact various bodily functions, including sex hormone production and regulation.
Sex Hormones and Fat Distribution
- Sex hormones influence fat storage location; estrogen leads to fat in breasts, hips, and buttocks, while androgens cause central fat.
- Different fat locations impact hormone production; subcutaneous fat releases beneficial hormones like leptin and adiponectin, while visceral fat releases inflammatory signals like TNF alpha.
Menopause and Fat's Role in Estrogen Production
- During menopause, ovaries shrink and produce fewer sex hormones, with androgens coming from adrenal glands.
- Fat tissue becomes the primary source of estrogens in post-menopausal women, converting adrenal androgens into estrogens.