The Optispan Podcast with Matt Kaeberlein

We'll Pay $101 Million If You Prove You Can Reverse Aging

Nov 18, 2025
Guest
Jamie Justice
In this enlightening discussion, Jamie Justice, Executive Vice President for Health and Director of the $101M XPRIZE Healthspan, dives into the ambitious goals of this global competition aimed at extending human healthspan. He shares insights on the challenges faced by past trials like TAME and the importance of real-world applications for the prize winners. Jamie discusses key healthspan pillars, ethical considerations in clinical trials, and the potential for innovative solutions like public health initiatives to win. Expect a mix of science, ambition, and a dash of the unusual!
Ask episode
AI Snips
Chapters
Transcript
Episode notes
INSIGHT

Prize Model Drives Scalable Impact

  • XPRIZE runs large-scale, prize-based competitions to drive capital and innovation toward big societal problems.
  • The model favors demonstrable impact and scalability over early-stage speculation.
INSIGHT

Choose Salient, Regulated Outcomes

  • Healthspan outcomes must be meaningful and telegenic to change public perception and policy.
  • XPRIZE prioritized outcomes with commercial pathways and regulatory feasibility, not just epigenetic clocks.
ADVICE

Prepare Trials And Data For Milestones

  • Teams must demonstrate R&D, secure regulatory paperwork, and run an early proof-of-concept clinic trial.
  • Submit de-identified data and show ability to collect, manage, and interpret raw trial data.
Get the Snipd Podcast app to discover more snips from this episode
Get the app