Lift Free And Diet Hard with Andrew Coates #407 Sam Miller - GLP-1 Agonist Drugs, Reverse Dieting, and Ultra Processed Foods
Oct 14, 2025
In this engaging discussion, Sam Miller, founder of Metabolism School and author of Metabolism Made Simple, delves into the rising popularity of GLP-1 agonists and their nuanced applications beyond just weight loss. He highlights the importance of strength training for muscle preservation when using these medications. The conversation also explores the concept of reverse dieting, detailing when it may be beneficial or harmful. Additionally, Sam tackles the complex role of ultra-processed foods in health, emphasizing a balanced approach instead of a blanket condemnation.
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GLP-1s Supercharge Satiety Signals
- GLP-1 drugs amplify the body's satiety hormone signal far beyond natural post-meal responses.
- Sam Miller warns this powerful hormonal 'hammer' changes appetite regulation and energy balance beyond simple appetite suppression.
Weigh Risks, Dose, And Duration
- Assess GLP-1 use by dose, duration, compound choice, and patient risk tolerance before prescribing.
- Consider provider practice style and financial incentives when evaluating whether use is appropriate.
Preserve Muscle With Training And Protein
- Do resistance training and prioritize high protein while on GLP-1s to preserve lean mass.
- Aim for ≥150 minutes weekly exercise and 3–4 sessions of progressive resistance to improve long-term outcomes.