The Metabolic Classroom with Dr. Ben Bikman Metformin: The Magic & Misery
May 21, 2021
Discover the ins and outs of metformin, the go-to diabetes drug, including how it works and its surprising risks. Learn about its dual role in enhancing insulin sensitivity while potentially causing nutrient deficiencies. Delve into the myths surrounding metformin's impact on muscle growth and longevity, and find out why lifestyle changes may be more effective than medication alone. Explore its effects on breastfeeding women and how personal empowerment is key to managing insulin resistance.
AI Snips
Chapters
Transcript
Episode notes
Metformin Works But Is Not A Cure
- Metformin is the most widely prescribed anti-diabetic drug and meaningfully improves insulin sensitivity.
- Ben Bikman rates it highest among insulin-sensitizing drugs but stresses it is not a cure for insulin resistance.
Gut Harm And B12 Risk
- Metformin commonly causes intestinal side effects including diarrhea, pain, and compromised nutrient absorption.
- Long-term use can reduce vitamin B12 absorption and cause clinically significant B12 deficiency.
Mitochondrial Complex I Is The Target
- Metformin inhibits mitochondrial complex I, slightly reducing ATP production and oxygen use.
- This induces AMPK activation, lowering oxidative stress and shifting cells toward energy breakdown.