JAMA Clinical Reviews Early-Onset Gastrointestinal Cancers
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Jul 17, 2025 In this discussion, Kimmie Ng, Associate Chief of Gastrointestinal Oncology at Dana-Farber Cancer Institute, reveals alarming trends in early-onset gastrointestinal cancers, particularly in patients under 50. She highlights the importance of recognizing modifiable risk factors like obesity and the psychological challenges young patients endure. The conversation also touches on updated screening guidelines for colorectal cancer and the role of Helicobacter pylori in esophagogastric cancers, emphasizing the urgent need for better diagnostic strategies.
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Rising Early-Onset GI Cancers
- Early-onset gastrointestinal cancers are rising globally, especially colorectal, pancreatic, and esophagogastric cancers.
- Obesity and environmental factors are key suspected contributors to this increasing incidence.
Modifiable Risk Factors to Manage
- Maintain a healthy weight and avoid obesity to reduce risk of early-onset GI cancers.
- Follow a balanced diet and stay physically active to lower colorectal cancer risk.
Genetics in Early-Onset GI Cancer
- Family history and genetic predisposition strongly increase risk of early-onset GI cancers.
- Lynch syndrome is the most common hereditary colorectal cancer condition.