Barbell Medicine Podcast Episode #368: The Rundown (4)
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Sep 30, 2025 
Dr. Austin Baraki, a physician and expert in clinical medicine, joins Dr. Jordan Feigenbaum to dive into a variety of intriguing topics. They discuss the unlikely scenario of a creatine overdose involving golfer Ben Griffin, critique cancer risk factors related to GLP-1 agonists, and unpack the new weight loss drug, MariTide. They also explore LeBron James' unusual exercise routines, the potential dangers of AI in medicine, and the impacts of plant-based diets on blood pressure.
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Golfer's 'Creatine Overdose' Story
- Ben Griffin claimed he "overdosed on creatine" after a poor stretch in a golf round and described tremors and shakiness.
- Dr. Austin Baraki and Dr. Jordan Feigenbaum doubted acute creatine toxicity and suggested contamination, caffeine, or acute anxiety as likelier causes.
GLP-1 Observational Cancer Signal Is Uncertain
- A retrospective study of ~43,000 GLP-1 users found a 17% lower overall cancer risk but immediate curve separation suggests bias.
- Dr. Austin Baraki cautions the result is hypothesis-generating and not definitive for clinical counseling.
Once-Monthly GLP Drugs Trade Ease For Titration Risk
- MariTide (cagiglutide) produced ~12–16% weight loss and is notable for once-monthly dosing and mixed GIP/GLP-1 pharmacology.
- Long-acting monthly drugs improve adherence but complicate dose titration and prolong side-effect duration.