The Body of Evidence 154 – Trump, RFK Jr, leucovorin, and autism
Oct 1, 2025
Dive into a thought-provoking discussion about the implications of leucovorin, a form of folinic acid, on autism treatment. Discover the differences between folic acid and folinic acid, and how folate's history has shaped health policies. Explore cerebral folate deficiency and its debated link to autism prevalence. The hosts scrutinize the recent FDA approval of leucovorin, potential conflicts of interest, and the current state of randomized trials. Are we rushing into uncharted waters? Tune in for a critical look at the intersection of science, politics, and health.
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Folinic Acid Is Different And Biologically Active
- Folinic acid (leucovorin) is the activated form of vitamin B9 and differs from folic acid used in pregnancy.
- It can bypass the enzyme blocked by methotrexate and enter cells without needing activation.
Cerebral Folate Deficiency Is A Transport Problem
- Cerebral folate deficiency describes low folate in the central nervous system despite normal blood levels.
- The problem can stem from impaired transport across the blood–brain barrier via specific receptors.
Cerebral Folate Explains Only Some Autism Cases
- Studies vary widely on how many autism cases involve cerebral folate deficiency, from small minorities up to claims of 30–50%.
- The more skeptical view is it likely explains only a small subset of autism cases.