Longevity by Design

How to Improve Your Healthspan Using DNA Insights with Dr. Bartek Nogal

Oct 11, 2023

Dr. Bartek Nogal discusses genetic predispositions to conditions of aging with Dr. Gil Blander, focusing on improving healthspan using DNA insights. They cover bone mineral density, epigenetic age acceleration, cognitive decline, risk of elevated ApoB, grip strength, and more. Understanding genetic predispositions helps fine tune wellness plans.

01:12:39

Episode guests

Bartek Nogal

AI Summary

Highlights

AI Chapters

Episode notes

Podcast summary created with Snipd AI

Quick takeaways

Tracking heart rate, blood biomarkers, and DNA helps gain biological context and optimize health.

Vigorous physical activity is the most important intervention for promoting longevity and overall health.

Polygenic scores provide personalized insights on health traits like visceral fat, muscle weakness, and cognitive aging, helping individuals take proactive measures for optimal health.

Deep dives

Tracking Health Parameters

One of the main ideas discussed in the podcast is the importance of tracking various health parameters like heart rate, blood biomarkers, and DNA to gain biological context and optimize health.

Understanding Polygenic Scores and Heritability

01:20

Importance of Monitoring LDL Levels Based on Genetic Risk

02:21

Introduction

2min

From Veterinary Medicine to Molecular Biology

5min

Understanding Genetic Variations: SNPs and DNA Overlap

23min

Measuring Blood and DNA for a Better Understanding of Health

6min

Improving Health and DNA Insights

2min

Predicting Risk of Health Conditions through DNA Analysis

15min

Polygenic Scores and Longevity

14min

The Importance of DNA Insights and Living a Better Longer

4min

In this episode of Longevity By Design, Dr. Gil Blander interviews Dr. Bartek Nogal about genetic predispositions to conditions of aging. This episode goes deep into explaining how to improve your healthspan using DNA insights. Dr. Blander and Dr. Nogal talk about bone mineral density, epigenetic age acceleration, cognitive decline, risk of elevated ApoB, grip strength, and more. Knowing your genetic predispositions to certain traits can help you fine tune your wellness plan, and Dr. Nogel and Dr. Blander explain how to do so in this episode.

Episode timestamps:

Introduction: (0:00–3:40)
What led Dr. Nogel to become a scientist (3:40–5:32)
Moving from academia to InsideTracker (5:32–7:28)
What is DNA? (7:28–9:12)
How similar is DNA across animal species? (9:12–10:05)
Single Nucleotide Polymorphisms (SNPs) (10:05–14:10)
How polygenic scores are calculated (14:10–17:25)
Defining heritability (17:25–22:53)
ApoB is highly heritable (22:53–24:24)
Why you should measure blood and DNA together (24:24–31:50)
Science behind the new polygenic scores added to InsideTracker (31:50–38:20)
How many SNPs are in the ApoB score? (38:20–41:20)
Visceral fat (41:20–45:07)
Age related muscle weakness (45:07–49:10)
Bone mineral density (49:10–51:45)
Chronotype—genetic predisposition to morningness (51:45–55:37)
Lifespan DNA score (55:37–60:10)
Epigenetic age acceleration (60:10–1:06:40)
Cognitive aging (1:06:40–1:08:20)
Age at menopause (1:08:20–1:10:40)
Top tip for healthspan: (1:10:40–end)

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Longevity by Design

How to Improve Your Healthspan Using DNA Insights with Dr. Bartek Nogal

Episode guests

Podcast summary created with Snipd AI

Quick takeaways

Deep dives

Tracking Health Parameters

Vigorous Physical Activity for Health

The Significance of Polygenic Scores

The Role of Epigenetics in Aging

Recommendations for Living a Longer, Healthier Life

Understanding Polygenic Scores and Heritability

Importance of Monitoring LDL Levels Based on Genetic Risk

Remember Everything You Learn from Podcasts