Longevity by Design

Dr. Evelyne Bischof, a physician-scientist and President of the Healthy Longevity Medicine Society, shares her journey into longevity medicine, emphasizing a shift from traditional healthcare to a focus on healthspan. She explains how advanced diagnostics, including AI, can personalize health trajectories and drive faster clinical innovations. Evelyne also discusses global advancements in longevity practices and the importance of data collection for empowering individual health decisions, aiming to establish longevity medicine as a recognized discipline.

In this episode of Longevity by Design, our host, Dr. Gil Blander talks with Dr. Renee Deehan and Paul Fabian about Inside Tracker's new Healthspan Habits Score feature. This innovative tool analyzes data from wearable devices and daily journal entries to identify the most impactful habit to improve each week for better health span and longevity.The guests explain how the algorithm processes up to 15 different variables, including sleep quality, step count, and lifestyle factors to create a personalized weekly score. Rather than overwhelming users with multiple recommendations, the report focuses on one key habit to change, applying behavioral science principles for sustainable improvement.Deehan and Fabian detail how the system evaluates six weeks of data to identify trends and provide targeted recommendations, helping users bridge the gap between blood tests with actionable weekly guidance based on scientific research linking these habits to longevity outcomes.Guest-at-a-Glance 💡 Name: Dr. Renee Deehan 💡 What she does: Senior Vice President of Science and Artificial Intelligence 💡 Company: InsideTracker 💡 Noteworthy: Expert in precision health with a PhD from UC Berkeley 💡 Where to find her:LinkedInGuest-at-a-Glance 💡 Name: Paul Fabian 💡 What he does: Researcher 💡 Company: InsideTracker 💡 Noteworthy: Specializes in genetics,  exercise biomarkers, and data-driven health recommendations 💡 Where to find him:LinkedIn Episode highlights:Introduction to Healthspan and Lifespan 00:00:00Meet the Experts: Dr. Renee Dhan and Paul Fabian 00:01:07Paul Fabian's Journey to Science 00:03:24Introducing the Health Span Habits Core Tool 00:04:31Inspiration Behind the Health Span Habits Core 00:05:07How the Health Span Habits Core Works 00:06:40Personalized Health Recommendations 00:08:02How does  Insight Tracker turn intent into action 00:10:16How the Health Span Habit Score is Calculated 00:13:25The Importance of Bedtime Consistency 00:22:00Behavioral Science in Health Tracking 00:25:35User Feedback and Future Directions 00:31:38Final Thoughts and Tips for Longevity 00:42:20 We Appreciate You!As a token of our gratitude, we’re excited to offer you 15% off your next purchase. Simply click the link below to redeem your discount: https://info.insidetracker.com/podcastFor science-backed ways to live a healthier, longer life, download InsideTracker's Top 5 biomarkers for longevity eBook at insidetracker.com/podcast

Dr. Daniel Durand, Chief Medical Officer at Prenuvo and a pioneer in radiology innovation, shares his insights on the transformative power of whole-body MRI in preventative health. He explains how this technology offers non-invasive, radiation-free scans that redefine early cancer detection. The conversation tackles misconceptions around overdiagnosis and highlights how AI in imaging can improve accuracy and reduce unnecessary procedures. Dr. Durand envisions a future where personalized data empowers patients to prioritize prevention over treatment.

Dr. Eran Segal, a Professor at the Weizmann Institute of Science, specializes in AI and personalized medicine. He discusses how AI and machine learning are reshaping nutrition and healthcare, emphasizing the need for robust data to enhance personalized health solutions. Eran envisions AI-powered digital twins for simulating lifestyle impacts on health, while cautioning against over-reliance on technology. He underscores that foundational habits like good nutrition, sleep, and exercise remain vital for longevity, showing that technology must work hand in hand with basic healthy choices.

Discover the potential of GLP-1 agonists, originally created for diabetes, now revolutionizing weight management and longevity. Learn how these drugs affect appetite, metabolism, and heart health. The conversation also explores the benefits of wearable tech like Apple Watch and Oura Ring, which enhance health tracking and fall prevention, particularly in older adults. With insights on personalized health strategies and the future of medical devices, this discussion emphasizes informed decision-making for better longevity and wellness.

Dr. Gabrielle Lyon, a board-certified family physician and bestselling author, discusses the alarming rise of sarcopenia and the impact of GLP-1 medications on muscle loss. She emphasizes the importance of muscle as a metabolically active organ crucial for longevity and introduces the concept of 'muscle span.' The conversation dives into dietary protein, advocating for higher intake for healthy aging, and addresses misconceptions about hormone replacement therapy. Lyon offers actionable insights to prioritize muscle health and enhance overall well-being.

On this episode of Longevity by Design, Dr. Gil Blander speaks with Dr. Michael Ringel, COO of Life Biosciences, about the science of aging and longevity. Michael discusses how evolution influences lifespan and why aging occurs. He explains the trade-off between resource allocation for reproduction versus maintenance and repair within the body. Caloric restriction and its effects on lifespan are explored through an evolutionary lens.Michael highlights the challenges and breakthroughs in longevity research. He touches upon the role of genetics and pharmaceuticals in manipulating lifespan and healthspan. He points to the Pacific rockfish as an example of varying lifespans within a closely related group of species, demonstrating the genetic component of aging. He also notes the impact of Cell reprogramming, referencing a study on how specific Cell reprogramming can regenerate optic nerves.The conversation shifts to the business of longevity, where Michael discusses the increased interest and investments from big pharma and billionaires. He examines the economic benefits of extending healthspan, citing a potential value of $300 trillion from a 10-year healthspan extension in the US alone. Michael and Gil also explore the importance of lifestyle choices for healthy aging, emphasizing diet, exercise, sleep, stress management, and social connections.Guest-at-a-Glance💡 Name: Dr. Michael Ringel 💡What they do: COO💡Company: Life Biosciences💡Noteworthy: Biotechnology COO bridging science and business for longevity breakthroughs.💡 Where to find them: LinkedIn   Episode highlights:[00:00:56] Meet Dr. Michael Ringel[00:02:30] Journey to Becoming a Scientist[00:04:26] Interest in Longevity and Aging[00:07:59] Evolution and Aging[00:21:04] Caloric Restriction and Lifespan[00:25:07] InsideTracker: Personalized Healthspan Optimization[00:26:02] Pharma's Role in Aging Research[00:37:32] Understanding Causality in Medical Research[00:38:09] Challenges of Observational Studies[00:39:40] Experimental Studies and the TAME Trial[00:40:21] Pharmaceutical Incentives and Metformin[00:40:56] Exploring Rapalogs and Patent Issues[00:43:39] Hallmarks of Aging and Future Prospects[00:45:59] Investment in Aging Research[00:52:35] Economic and Social Impacts of Longevity[01:02:30] Practical Tips for Extending Lifespan For science-backed ways to live a healthier longer life, download InsideTracker's Top 5 biomarkers for longevity eBook at insidetracker.com/podcast

In this engaging discussion, Dr. S. Jay Olshansky, a professor specializing in aging and biodemography, sheds light on the biological limits of human longevity. He reveals how advancements in public health have dramatically increased life expectancy, yet gains are slowing. The conversation dives into the intricate relationship between genetics and lifestyle choices, as well as societal factors affecting longevity. Dr. Olshansky emphasizes the importance of sustainable health practices over pharmaceutical fixes, offering practical tips for enhancing both lifespan and healthspan.

Can personalized medicine unlock the secrets to living longer and healthier lives? In this episode of Longevity by Design, host Dr. Gil Blander sits down with Dr. David Barzilai, a renowned longevity physician and founder of Barzilai Longevity Consulting, to explore the science of extending healthspan through precision and innovation.Dr. Barzilai shares his journey into biogerontology and longevity science, unpacking key concepts like the hallmarks of aging, the potential of lifestyle interventions, and the translation of findings from animal models to human health. He highlights how evidence-based lifestyle medicine—centered on nutrition, exercise, sleep, and stress management—can be tailored to individual needs using biomarker-driven strategies for maximum impact.The conversation delves into some of the most promising longevity interventions, from gerotherapeutics to cutting-edge supplements. Dr. Barzilai emphasizes the power of personalized approaches in optimizing healthspan and lifespan, offering listeners practical, science-backed insights to take charge of their longevity journey.Engaging and informative, this episode is essential listening for anyone curious about the future of longevity medicine and the innovations shaping how we age. Guest-at-a-Glance💡 Name: Dr. David Barzilai, MD, PhD💡What he does: Founder and CEO💡Company: Healthspan Coaching LLC💡Noteworthy: Renowned longevity physician integrating science and personalized health strategies.💡 Where to find them: LinkedIn, Twitter  Episode highlights:Introduction: 00:00:00Dr. Barzilai’s Journey into Science: 00:03:43The Importance of Translating Science into Practice: 00:10:00The Role of Social Media in Longevity Science: 00:16:37Defining Biogerontology: 00:22:32Understanding the Hallmarks of Aging: 00:24:27The Role of Lifestyle Medicine in Preventing Premature Mortality: 00:36:13Caloric Restriction and Its Effects on Lifespan: 00:37:33Human Trials and the Challenges of Compliance: 00:41:13The Potential of Rapamycin and mTOR Inhibitors: 00:42:05The Importance of Lifestyle Medicine: 00:51:25Precision Medicine: Tailoring Health Interventions: 01:02:56GLP-1 and Alcohol Absorption: 01:12:30Exercise and Mortality Reduction: 01:15:33Biomarkers and Metabolic Health: 01:19:38Longevity Drugs and Supplements: 01:25:43Epigenetic Reprogramming and Aging: 01:45:06For science-backed ways to live a healthier longer life, download InsideTracker's Top 5 biomarkers for longevity eBook at insidetracker.com/podcast

Dr. Dmitriy Richard Starson, Founder and CEO of Passio, discusses his fascinating journey from astrophysics to creating an AI nutrition coaching platform. He details how Passio's technology revolutionizes food tracking through AI-driven tools like food scanning and voice logging. Dmitriy envisions a future where personalized nutrition is as common as fitness tracking, potentially slowing aging. He addresses the importance of accurate dietary data and the synergy between AI and human expertise in enhancing health outcomes.