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Inotropes and Cardiac Contractility
- Inotropes alter cardiac muscle contraction force, increasing cardiac output.
- They increase intracellular calcium via cyclic AMP, activating L-type calcium channels.
Inotrope Classification
- Inotropes are classified as cyclic AMP dependent or independent.
- Cyclic AMP dependent inotropes include adrenergic agonists, phosphodiesterase inhibitors, and glucagon.
Cyclic AMP Independent Inotropes
- Cyclic AMP independent inotropes include calcium, calcium sensitizers, and sodium-potassium ATPase inhibitors.
- Triiodothyronine is also included, supporting cardiac protein synthesis.