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Intelligence Squared

The New Science Behind Tackling Depression

Sep 28, 2023
Join Philip Gold, a leading researcher of depressive illness and author of 'Breaking Through Depression', alongside Güneş Taylor, a science communicator at The Francis Crick Institute. They dissect the complexities of depression, comparing melancholic and atypical forms, and delve into the effects of early trauma. Their discussion introduces innovative treatment approaches, including SSRIs and psychedelics, advocating for a personalized and holistic perspective on mental health that challenges traditional views.
32:15

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Quick takeaways

  • Depression can manifest in different ways, such as melancholic and atypical depression, each with distinct symptoms and underlying causes.
  • Depression not only impacts mental well-being but also has significant physiological effects, contributing to physical health conditions like cardiovascular disease and osteoporosis.

Deep dives

Differentiating Types of Depression

Depression is a disorder that arises from a combination of environmental factors and genetics. There are two main types of depression: melancholic and atypical depression. Melancholic depression is characterized by a depressed mood, anxiety, feelings of worthlessness, and a loss of pleasure. It is associated with physiological changes such as stress hormone activation, sleep disturbances, and weight loss. On the other hand, atypical depression is characterized by a sense of disconnection, increased sleep and appetite, and a lack of response to stimuli. It often stems from early life trauma and does not exhibit severe anxiety.

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