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Curiosity Weekly
Cryopreservation, Personality Transplant, Fungal Azoles
Aug 22, 2024
Join Weiwei Xue, a pioneering researcher in cryopreservation techniques for human brain tissue, alongside Hao Chen, who focuses on brain organoids, and Brian Callahan, an expert on personality changes post-transplant. They discuss breakthrough cryopreservation methods that could change neuroscience. Fascinatingly, they delve into how organ transplant recipients often experience shifts in personality, possibly influenced by their donors. The conversation also touches on the impact of azole fungicides on combating fungal diseases, highlighting new mechanisms of action.
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Quick takeaways
- The METI method significantly enhances cryopreservation of brain organoids, preserving their structure and function for improved research opportunities.
- Approximately 89% of organ transplant recipients experience notable personality changes, raising questions about potential memory transfer from donors.
Deep dives
Innovative Cryopreservation of Brain Organoids
A new method called METI has been developed to effectively cryopreserve brain organoids, which are 3D models derived from human stem cells that mimic brain development. Traditional preservation techniques struggle to maintain the delicate structure and function of brain tissue, limiting research opportunities. The METI process involves a precise combination of compounds and protocols that allow for successful freezing and thawing, resulting in preserved neural structure and activity. This advancement enables large-scale storage of organoids, potentially leading to accelerated drug discovery and personalized treatments tailored to specific patients.
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