Guests Brian Callahan, Jim Harbaugh, Antonio Pierce, and Nick Sirianni talk about various unsolved mysteries in the NFL postseason. They discuss the Titans' hiring of Brian Callahan, Jim Harbaugh potentially becoming the Chargers' head coach, Antonio Pierce joining the Raiders, and Nick Sirianni staying with the Eagles. They also explore mysteries surrounding Bill Belichick and the Falcons, the Lions defense, and offseason moves by the Buccaneers and Dolphins.

Join Weiwei Xue, a pioneering researcher in cryopreservation techniques for human brain tissue, alongside Hao Chen, who focuses on brain organoids, and Brian Callahan, an expert on personality changes post-transplant. They discuss breakthrough cryopreservation methods that could change neuroscience. Fascinatingly, they delve into how organ transplant recipients often experience shifts in personality, possibly influenced by their donors. The conversation also touches on the impact of azole fungicides on combating fungal diseases, highlighting new mechanisms of action.

Former NFL offensive lineman Mitchell Schwartz and Robert Mays evaluate top NFL teams' off-seasons. Titans head coach Brian Callahan discusses coaching in Tennessee, Will Levis, and coaching with his dad. The episode covers draft moves, play-calling experiences, and a 'buy or sell' series on NFL offseasons.