Rogue State of Mind

How Genetic Mutations Affect Your Vitamin D Status with Dr Tyler Panzner

Sep 15, 2023

Dr Tyler Panzner, PhD in Molecular and Cellular Pharmacology, discusses how genetic mutations affect vitamin D status. He explains the biphasic dose response curve, the importance of vitamin D signaling, and alternative supplements. The conversation also covers NAC supplements, melatonin demonization, and the benefits of lithium. They explore iron and ferritin levels, controversy over supplements, limitations of clinical trials, and personalized approaches. They touch on vitamin A requirements, borage oil benefits, and the use of lithium for stress and anxiety. Magnesium reactions, red light therapy, holistic health optimization, and genetic mutations' impact on essential oil shampoo are also discussed.

01:57:18

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Episode guests

Tyler Panzner

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Quick takeaways

Genetic mutations can affect the absorption and activation of vitamin D, determining the need for supplementation.

Traditional vitamin D supplements may not raise vitamin D levels for many individuals, highlighting the importance of personalized approaches.

Vitamin D plays a role in mood regulation and seasonal depression, with genetic mutations impacting its effects on mental health.

Cross-referencing various genes and pathways can optimize health outcomes and individual responses to supplementation.

Deep dives

Genetic mutations can impact vitamin D absorption and activation

Dr. Tyler Pansner discusses how genetic mutations can affect the absorption, transport, storage, and activation of vitamin D. These mutations determine whether an individual can obtain vitamin D from sunlight or if they need to supplement it.

Impact of Individual Health Conditions on Rate of Improvement

02:00

Impact of Accumulated Lesser Significant Genetic Mutations

01:23

Impact of CBS Gene Mutation on Homocysteine Levels and Glutathione Production

01:32

Key Factors in Health Assessment and Recommendations

01:37

Introduction

3min

Genetic Mutations and Vitamin D Status

28min

Understanding the Complexity of Iron and Ferritin Levels

12min

Controversy and Frustration: The Debate Over Supplements

12min

The Limitations of Clinical Trials and Individualized Approaches to Medication

17min

Understanding Genetic Mutations and Vitamin A Requirements

2min

Exploring the Benefits of Borgseed Oil for Joint Inflammation and Histamine Release Prevention

2min

The Benefits of Lithium for Stress and Anxiety

25min

Exploring Magnesium Reactions and Red Light Therapy Benefits

3min

10.

Holistic Genetic Health Optimization

13min

11.

Genetic Mutations and Essential Oil Free Shampoo & Conditioner

2min

Many practitioners tell people to never supplement vitamin D. This was my belief system for several years because on the surface it made sense. When I dug deeper I found that there is something called a "biphasic dose response curve". That is a fancy way of saying: Take too much or too little and either way will increase calcification of soft tissues (Drueke, et al 2012).

Dr Tyler Panzner has a PhD in Mollecular and Cellular Pharmacology and looks at nutritional supplementation through a genetic mutations lens. In this episode he gives a brief explanation of how genetics works, how he was deficient in vitamin D on the beach in the middle of summer, why he believes vitamin D signaling is more important than blood levels, what he thinks about lab reference ranges, an alternative vitamin D supplement to cholecalciferol that he thinks works better, and some of the genetic mutations to look for if you suspect you are deficient.

He also talks about why he thinks NAC supplements are overrated, the demonization of melatonin supplements, borage oil, and gives a mini consultation looking at my genetic mutations with B12 and how supplementing lithium can help mitigate them.

Work with Dr Tyler Panzner: https://drtylerpanzner.com/home

My website: www.matt-blackburn.com

Mitolife products: www.mitolife.co

Music by George Henner: https://georgehenner.bandcamp.com/