How Genetic Mutations Affect Your Vitamin D Status with Dr Tyler Panzner
Sep 15, 2023
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Dr Tyler Panzner, PhD in Molecular and Cellular Pharmacology, discusses how genetic mutations affect vitamin D status. He explains the biphasic dose response curve, the importance of vitamin D signaling, and alternative supplements. The conversation also covers NAC supplements, melatonin demonization, and the benefits of lithium. They explore iron and ferritin levels, controversy over supplements, limitations of clinical trials, and personalized approaches. They touch on vitamin A requirements, borage oil benefits, and the use of lithium for stress and anxiety. Magnesium reactions, red light therapy, holistic health optimization, and genetic mutations' impact on essential oil shampoo are also discussed.
Genetic mutations can affect the absorption and activation of vitamin D, determining the need for supplementation.
Traditional vitamin D supplements may not raise vitamin D levels for many individuals, highlighting the importance of personalized approaches.
Vitamin D plays a role in mood regulation and seasonal depression, with genetic mutations impacting its effects on mental health.
Cross-referencing various genes and pathways can optimize health outcomes and individual responses to supplementation.
Deep dives
Genetic mutations can impact vitamin D absorption and activation
Dr. Tyler Pansner discusses how genetic mutations can affect the absorption, transport, storage, and activation of vitamin D. These mutations determine whether an individual can obtain vitamin D from sunlight or if they need to supplement it.
Favorite form of vitamin D supplement and its benefits
Dr. Pansner shares his preferred form of vitamin D supplement, different from Cola calciferol, and explains why traditional D supplements may not raise vitamin D levels for many individuals. He also emphasizes the importance of vitamin D signaling over blood levels.
The relationship between vitamin D and mood
Vitamin D plays a significant role in mood regulation, as it epigenetically upregulates genes responsible for dopamine and serotonin production. Seasonal depression is often linked to low sunlight exposure and vitamin D deficiency. Genetic mutations can also impact vitamin D's effects on mental health.
The importance of individualized supplement recommendations
Dr. Pansner advocates for personalized approaches to supplementation, considering an individual's unique genetic mutations and specific needs. He emphasizes the significance of cross-referencing various genes and pathways in order to optimize health outcomes.
Importance of Individualized Supplement Response
Individuals respond differently to supplements due to their unique genetics and biochemistry.
Understanding Genetic Mutations
Genetic mutations can affect how the body absorbs and utilizes nutrients, leading to individual differences in supplement response.
The Role of Vitamin D
Vitamin D levels can be influenced by genetic mutations and cofactors, such as magnesium and boron.
Exploring Red Light Therapy and Lithium
Red light therapy and lithium supplementation can have beneficial effects on various health aspects, including nitric oxide levels, mood regulation, and histamine response.
Many practitioners tell people to never supplement vitamin D. This was my belief system for several years because on the surface it made sense. When I dug deeper I found that there is something called a "biphasic dose response curve". That is a fancy way of saying: Take too much or too little and either way will increase calcification of soft tissues (Drueke, et al 2012).
Dr Tyler Panzner has a PhD in Mollecular and Cellular Pharmacology and looks at nutritional supplementation through a genetic mutations lens. In this episode he gives a brief explanation of how genetics works, how he was deficient in vitamin D on the beach in the middle of summer, why he believes vitamin D signaling is more important than blood levels, what he thinks about lab reference ranges, an alternative vitamin D supplement to cholecalciferol that he thinks works better, and some of the genetic mutations to look for if you suspect you are deficient.
He also talks about why he thinks NAC supplements are overrated, the demonization of melatonin supplements, borage oil, and gives a mini consultation looking at my genetic mutations with B12 and how supplementing lithium can help mitigate them.