Bloody Minded Episode 42 - In The Lab: Rare Groups, Subgroups, Elutes and Fruit Loops | Advanced Blood Banking
Apr 15, 2025
Delve into the fascinating world of rare blood groups and their impact on transfusion medicine. Explore the complexities of blood types and how racial variations influence practices in blood banking. Learn about advanced techniques like enzyme treatments that help in identifying antigens and resolving discrepancies. Discover the importance of specific blood group systems like Kell, Duffy, and Kidd, while also uncovering the challenges posed by monoclonal antibodies. It's a deep dive into the intricate, often overlooked, aspects of blood banking.
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Impact of Genetic Variation on Blood
- People have different red cell antigen expressions based on race and genetics.
- This variation impacts blood matching and antibody production globally.
Henry VIII and Kel Antigen
- Henry VIII may have been Kel positive, possibly explaining the loss of many children.
- McLeod syndrome causes weak Kel antigen expression with neurological symptoms.
Duffy Null's Dual Impact
- Duffy null phenotype protects against malaria by blocking Plasmodium vivax entry.
- It also causes lower neutrophil counts known as Duffy Null Associated Neutrophil Count (DANC).