Gladden Longevity Podcast -- formerly Living Beyond 120 NAD: The Key to Aging Gracefully - Episode 304
Oct 2, 2025
In this engaging discussion, Dr. Nichola Conlon, a PhD biochemist and developer of the Nuchido Time formulation, unpacks the vital role of NAD in cellular repair and aging. She delves into how NAD levels drop with age and the implications of this decline, particularly relating to inflammation. Dr. Conlon shares insights on effective strategies for restoring NAD, including her innovative product design. They also tackle the ineffectiveness of IV NAD therapies and the importance of customer feedback in shaping future research and product development.
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NAD Must Be Intracellular To Work
- NAD fuels cellular repair processes and must be inside cells to function.
- An IV puts NAD into blood, not cells, so it rarely raises intracellular NAD effectively.
NAD Is Central To Multiple Aging Hallmarks
- NAD depletion links to many hallmarks of aging and shows pleiotropic effects.
- Restoring NAD can simultaneously improve multiple aging pathways.
Demand + Declining Recycling Create NAD Shortage
- Two root causes reduce NAD with age: higher demand for repair and lower recycling capacity.
- The salvage pathway and its rate-limiting enzyme decline, creating a shortage.