Gladden Longevity Podcast -- formerly Living Beyond 120

NAD: The Key to Aging Gracefully - Episode 304

Oct 2, 2025

In this engaging discussion, Dr. Nichola Conlon, a PhD biochemist and developer of the Nuchido Time formulation, unpacks the vital role of NAD in cellular repair and aging. She delves into how NAD levels drop with age and the implications of this decline, particularly relating to inflammation. Dr. Conlon shares insights on effective strategies for restoring NAD, including her innovative product design. They also tackle the ineffectiveness of IV NAD therapies and the importance of customer feedback in shaping future research and product development.

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INSIGHT

NAD Must Be Intracellular To Work

NAD fuels cellular repair processes and must be inside cells to function.
An IV puts NAD into blood, not cells, so it rarely raises intracellular NAD effectively.

INSIGHT

NAD Is Central To Multiple Aging Hallmarks

NAD depletion links to many hallmarks of aging and shows pleiotropic effects.
Restoring NAD can simultaneously improve multiple aging pathways.

INSIGHT

Demand + Declining Recycling Create NAD Shortage

Two root causes reduce NAD with age: higher demand for repair and lower recycling capacity.
The salvage pathway and its rate-limiting enzyme decline, creating a shortage.

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In this episode of the Gladden Longevity Podcast, Dr. Jeffrey Gladden and Dr. Nichola Conlon delve into the complexities of aging, focusing on the important role of NAD (Nicotinamide Adenine Dinucleotide) in cellular health and longevity. They discuss how NAD levels decline with age, the implications of this decline, and innovative strategies to boost NAD levels effectively. The conversation also touches on the limitations of IV NAD therapy, the importance of addressing inflammation, and the scientific validation behind the Nuchido Time product. Dr. Conlon shares insights into future research directions and the impact of customer feedback on product development, emphasizing the need for a comprehensive approach to enhancing cellular health.

For Audience

· Use code 'Podcast10' to get 10% OFF on any of our supplements at https://gladdenlongevityshop.com/ !

· www.nuchido.com/GLADDEN or simply use code GL20 at Checkout on www.nuchido.com for 20% off your first order!

Takeaways

NAD is crucial for driving cellular repair processes.
The decline of NAD is linked to aging and inflammation.
Addressing root causes of NAD decline is essential.
IV NAD therapy may not effectively increase intracellular NAD levels.
NAD recycling is a complex process influenced by various enzymes.
Chronic inflammation can significantly deplete NAD supplies.
Nuchido Time aims to optimize NAD levels through a comprehensive approach.
Customer feedback drives ongoing research and product development.
NAD levels fluctuate throughout the day, impacting circadian rhythms.
Future studies will explore NAD's effects on sleep and skin quality.

Chapters

00:00 Introduction and Background

04:00 The Importance of NAD in Aging

07:45 Understanding NAD Depletion and Its Causes

12:47 The Role of CD38 in NAD Dynamics

16:42 Innovative Approaches to NAD Supplementation

21:26 Comparing NAD IVs and Oral Supplements

25:12 Enhancing NAD with Ozone Therapy

28:04 Product Development and Optimization

33:47 Future Research Directions and Applications

To learn more about Dr. Nichola Conlon: Website: www.nuchido.com Email: care@nuchido.com Social media: @nuchido @drnicholaconlon

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