Dhru Purohit Show

This Study Shocks Cardiologists: LDL and ApoB May Not Predict Heart Disease Risk in Healthy People with Dr. Nick Norwitz

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Apr 7, 2025
In a riveting discussion, Dr. Nick Norwitz, a researcher and advocate for metabolic health, challenges the traditional view of LDL cholesterol as a sole predictor of heart disease risk. He highlights the complexities of plaque progression and emphasizes the need for personalized nutrition and lifestyle choices. Topics range from the impact of diet on heart health to the influence of genetics and microplastics. Dr. Norwitz also critiques current testing methods, advocating for a more nuanced understanding of cardiovascular risk.
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INSIGHT

LDL and Heart Disease Risk

  • High LDL cholesterol doesn't always mean high heart disease risk.
  • A groundbreaking study on "lean mass hyper-responders" showed minimal plaque progression despite high LDL, challenging conventional wisdom.
ANECDOTE

Oreo Cookie Experiment

  • Nick Norwitz lowered his cholesterol by eating Oreo cookies to highlight interesting physiology.
  • This "clickbait" study sparked conversations about cholesterol and metabolic responses.
ADVICE

Personalized Risk Assessment

  • Get functional tests like coronary artery calcium scans to assess heart health.
  • Know your insulin resistance score, lipid panel, and inflammation markers.
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